Get ready for Sunday Night Football! Explore the latest odds and expert picks for the thrilling matchup between the San Francisco 49ers and Buffalo Bills.
The Buffalo Bills might be the first team to lock up a division title this season. Buffalo is 9-2 and four games ahead of the Miami Dolphins in the AFC East with six games left to play. The Bills have won six straight games after losing to the Houston Texans, and they are coming off a big win over the Kansas City Chiefs two weeks ago. That has led to the oddsmakers installing the Bills as a touchdown favorite per the NFL betting odds against the San Francisco 49ers on Sunday Night Football.
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Week 13 San Francisco 49ers at Buffalo Bills
San Francisco 49ers +7
Buffalo Bills -7
Total 44
If you would have asked an oddsmaker to set a line for the Chris Berman Bowl a few weeks ago, Buffalo would have been around a four-point favorite. However, San Francisco is in disarray at 5-6, and the Niners might not have Brock Purdy available again this week due to a shoulder injury. Purdy missed last week’s game against Green Bay, and Brandon Allen was not effective in relief. That has led to the total in this game falling from 46 to 44.
San Francisco 49ers Overview
It looks like Brandon Allen will start over Brock Purdy once again if you read the tea leaves. Allen did not play well against Green Bay last week, completing 17 of 29 passes for 199 yards with a touchdown and an interception. The offense finished with just 241 total yards and turned the ball over three times with Allen under center, and a similar performance would probably lead to a Buffalo blowout.
San Francisco needs some help in the ground game, but Christian McCaffrey and Jordan Mason combined to carry the ball 14 times for 39 yards last week. McCaffrey has been one of the most disappointing performers this season, and he has been limited as a receiver due to the injury that kept him out of the first half of the campaign.
Injuries have destroyed San Francisco this season. Deebo Samuel and McCaffrey are back, but Brandon Aiyuk is gone for the season. Three starting offensive linemen (including Trent Williams) are questionable to suit up on Sunday night, and the defense has been ravaged by injuries. Arguably the most talented unit in the league no longer has Javon Hargrave, Talanoa Hufanga, and Dre Greenlaw. Nick Bosa is banged up and missed last week’s game, and there are lots of injuries in the two-deep.
Buffalo Bills Overview
Josh Allen is currently the favorite to be named the NFL MVP per the football futures odds. Allen has had a phenomenal season even though he no longer has a true No. 1 receiver. Stefon Diggs and Gabe Davis both left in the offseason, but Allen is completing 64% of his passes for 2,543 yards with 18 touchdowns and five interceptions. He has only been sacked 13 times in 11 games, yet he has run for 316 yards and five touchdowns.
Khalil Shakir has been the top receiver for the Bills, and Dalton Kincaid is the reliable option at tight end. Rookie Keon Coleman is Buffalo’s big play threat, but both Kincaid and Coleman are considered questionable this week due to injury.
Third year running back James Cook isn’t having as strong of a season as he did last year, but he has been effective. Cook has run for 596 yards and 10 touchdowns, and he is averaging 4.3 YPC. That has helped the Bills average 29.1 PPG, ranking third in the NFL in that category.
Buffalo’s run defense hasn’t been great. The Bills are allowing 4.9 YPC on the ground, as the linebackers haven’t been great in their run fits. However, the secondary has been pretty good, and the Bills have been able to force a lot of turnovers.
Sunday Night Football Prediction
Snow is in the forecast for most of the next week in Buffalo, but it is supposed to let up on Sunday night. That will give the Over a chance if Purdy is healthy and plays. If Allen suits up, the Under and Buffal are the bets though as long-time backup is just 2-8 in his career as a starter.
Final Score: Buffalo 24, San Francisco 14
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